Panorama test

Panorama™ – Noninvasive prenatal testing (NIPT)

Panorama™ is a blood-based genetic, prenatal screening test of the pregnant person that screens for common chromosomal conditions that affect a baby’s health. Panorama™ uses SNP*-based technology to deliver highly accurate results and unique insights for both singleton and twin pregnancies.

Panorama™ is a screening test, which means that this test does not make a final diagnosis. A high risk result means that your pregnancy has a higher chance of having a specific genetic condition. However, you cannot know for sure if your baby has that condition based upon the screening result alone. All medical decisions should be made after discussion with your healthcare provider regarding diagnostic testing during the pregnancy, like chorionic villus sampling (CVS) or amniocentesis, or testing the baby after birth. *SNP, single nucleotide polymorphism

The Panorama™ difference

The only SNP-based NIPT, designed to inform decisions during pivotal moments of pregnancy care. A differentiated, highly-accurate screening approach evaluates SNPs – the 1% of our DNA that makes us different from one another – to screen for common trisomies, aneuploidies and microdeletions. A sequencing platform of >13K SNPs enables Panorama to deliver a curated prenatal cfDNA screening test that accounts for all ethnicities and population variability.

Validated with clinical rigor

SMART, the largest prospective NIPT study, evaluated the performance of SNP-based NIPT in a real-world population. All results included in the analysis were validated with genetic confirmation. ZERO fetal sex errors in validation studies > 95% positive predictive value (PPV) for trisomy 21 83% clinical sensitivity for 22q11.2 deletions (0.5 Mb+ deletions) > 99% combined sensitivity for trisomies (T21, T18, T13)

Panorama screens for common genetic conditions that are caused by extra or missing chromosomes in the baby’s DNA. Because Panorama uses a unique technology to distinguish between the pregnant person’s and the baby’s DNA, it is the only NIPT that tests for triploidy. Some conditions, such as Down syndrome, are caused by extra copies of a specific chromosome. Others, such as microdeletions, occur when a chromosome is missing a small piece of genetic information.

Conditions Screened For:

Trisomies: *

• Down syndrome/trisomy 21
• Edwards syndrome/trisomy 18
• Patau syndrome/trisomy 13

Sex chromosome aneuploidies: **

• Monosomy X (Turner syndrome)X
• XXY Syndrome (Klinefelter Syndrome)
• Triple X syndrome
• XYY Syndrome (Jacob’s Syndrome)

Microdeletions: **

• 22q11.2 deletion syndrome
• Prader-Willi syndrome †
• Angelman syndrome †
• 1p36 deletion syndrome
• Cri-du-chat syndrome

Triploidy: **

• Only NIPT that tests for triploidy

** Not available for egg-donor or gestational carrier pregnancies or in cases of dizygotic (nonidentical) twins. Triploidy and microdeletions except for 22q11.2 deletions are not available for monozygotic (identical) twins.

† This test has been validated on full region deletions of Prader-Willi syndrome/Angelman syndrome (PWS/AS) only and might be unable to detect smaller deletions. It has not been validated for other molecular mechanisms which could cause PWS/AS such as uniparental disomy (UPD) or methylation.

Microdeletions package can not be ordered for twin pregnancy.
Microdeletions package can not be ordered separately.

Who should have Panorama™ prenatal screen?

The Panorama™ prenatal screen is designed for women of any age and ethnicity who are at least 9 weeks pregnant. It cannot currently be used by women carrying three or more babies (triplets and above), women who have used an egg donor or surrogate carrying more than one baby (twins or triplets), or those who have received a bone marrow transplant.

What are the benefits of having the Panorama™ prenatal screen?

As early as 9 weeks into your pregnancy, a simple blood draw can tell you if your baby is at higher risk for having Down syndrome and other common genetic conditions, as well as the sex of your baby. Noninvasive and highly accurate, Panorama™ identifies more than 99% of pregnancies affected with Down syndrome and has the lowest reported false positive rate of any prenatal screening test for the commonly screened chromosomal abnormalities: trisomy 21, trisomy 18, and trisomy 13.

Screening for egg donor pregnancies

Conditions screened in egg donor pregnancies:

• Trisomy 21 (also known as Down syndrome)
• Trisomy 18 (also known as Edwards syndrome)
• Trisomy 13 (also known as Patau syndrome)

Why it is important to know whether the twins are identical or not?

This information helps your healthcare provider to determine the appropriate amount of follow-up and what specialists may be necessary for your pregnancy. Identical twins may share a placenta. A shared placenta can increase the chance for unequal growth and a severe condition called twin-twin transfusion syndrome (TTTS). There is no risk of TTTS for fraternal twins.

Panorama can provide risk evaluation for more conditions than any other non-ivasive prenatal test for twins:

Down syndrome, Edwards syndrome, and Patau syndrome Turner syndrome, a genetic disorder that occurs in girls that is associated with heart defects, learning difficulties, and infertility 22q11.2 deletion syndrome, a genetic disorder that occurs in boys and girls that is associated with learning differences, heart defects, and other birth defects* *Risk evaluation available for pregnancies determined by Panorama to involve identical twins/p>

For twin pregnancies, only Panorama can provide:

• Zygosity information
• Individual fetal fractions for dizygotic twins
• Fetal sex for each twin
• Monosomy X risk for monozygotic twins

Panorama helps clinicians identify higher risk for conditions that affect more than 1 in 45 twin pregnancies.